Ketamine-Assisted Psychedelic Therapy

Welcome to the space beyond this space, and the world of Psychedelic Ketamine.

How does one describe the felt sense within our own being of the space between the stars? The vastness, richness, spaciousness, depth? How do we describe that final letting go of something we’ve been holding onto for most of our lives? Or for many lifetimes? That sense of release and final surrender, leading to a spacious and enveloping cushion of euphoria and an incredible, authentic sense of wellbeing. How do we describe waking up to Self and our potential and realizing that we are already okay? How does one describe these things?


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At the Center for Medicinal Mindfulness, we use potent, weight-based doses of intramuscular ketamine in a two step process to induce a non-ordinary state of consciousness that leads to these profound psychedelic and euphoric states of being.

While ketamine has been found to support the healing of depression, it has been our experience that combining techniques of Ketamine Assisted Psychotherapy with Mindfulness-Based Psychedelic Therapy within a respectful, transpersonal setting, these beneficial results are amplified further. This modality is known in our practice as Ketamine-Assisted Psychedelic Therapy. Many of our clients report significant relief from depression, anxiety, PTSD, trauma and addiction. On the growth edge of psychedelic journeywork, Ketamine is an incredible expedition tool of consciousness, leading to vast landscapes of ancient and otherworldly imagery. It is truly an otherworldly experience. 

Psychedelic Intensives with Ketamine

Visit Psychedelic Intensives & Pricing to learn more about these intensives. A very brief description of each is provided here for your reference. All intensives include the necessary preparation and integration support and these sessions are added to the total hours of the series below. 

  • Luminous – (8 hour intensive) – two ketamine sessions over a 3 day period
  • Luminous Star – (15 hour intensive) – four 3-hour ketamine sessions (1-2 per week) Luminous Nova – (22 hour intensive) – six 3-hour ketamine sessions (1-2 per week) 
  • Sanctuary – (19 hour intensive) – two psychedelic cannabis and two ketamine sessions in a weeklong retreat
  • Explorer – (18 hour intensive) – a single psilocybin mushroom session between two ketamine sessions
  • Helix Explorer – (27 hour intensive) – two psilocybin mushroom sessions between two ketamine sessions, usually over a one to two week period
  • Short Explorer – (15 hour intensive) – a single ketamine experience followed by a psilocybin mushroom journey, great for 2 or 3 day, shorter expedition in consciousness

Dreamer (+3 hours as add-on or 5 hours as standalone)  – a single DMT session with 2 journeys. Dreamer can be added to any of the above intensives, such as: Luminous Dreamer, Dreaming Sanctuary, Dream Explorer.

What is Ketamine?

Ketamine is a prescribed medication and is a safe, legal, and highly effective psychedelic. It is a dissociative anesthetic commonly used in surgeries and hospitals worldwide and has been safely administered on humans for decades. An unusual, but very common side effect of ketamine is its psychedelic nature. 

Ketamine is proving successful in providing significant symptom relief for depression, and the off label treatment of post-traumatic stress disorder (PTSD), anxiety, addiction, and other mental health conditions when administered in conjunction with professional support and guidance.

What are the Psychedelic Effects of Ketamine?

Many of the psychedelic effects of ketamine are unique and include:

  • The anesthetic quality of ketamine significantly reduces the intensity of physical and emotional pain and tension, giving a chance for the psyche to recalibrate to a new possibility of being.
  • The dissociative quality of ketamine is often experienced as an “out of body” experience, giving a sense of greater objectivity and awareness of underlying problems and concerns, often leading to a sense of resolution. Clients report seeing a bird’s eye view of their ordinary life and struggles, which allows them to gain new perspectives and resilience in their lives. This quality of dissociation increases with stronger doses, creating a sense of vastness, and a sense of consciousness that transcends the body and steps into a more universal awareness not touched by our day to day struggles. 
  • As pains and tensions decrease, ketamine provides a reprieve and a deep, full system reset, which feels like being enveloped by an authentic, felt sense of euphoria and rest.
  • Accompanied by this vast sense of spaciousness in being is a very vivid, psychedelic, imaginal inner visual experience. The inner experience can be very personal, reliving significant memories in a way that is reconciling, or very transpersonal, often described as moving through the universe, seeing alien landscapes, vast architecture and the undulating unfolding of being. It is a fully immersive psychedelic experience. 

In addition to the acute effects of the ketamine experience, after-effects are also commonly reported that include:

  • Lasting felt sense of relief and a full system recalibration
  • Reduction in symptoms of depression and trauma
  • Greater agency and choice around old, habitual patterns, and less withdrawal symptoms related to alcoholism and addiction
  • Clients often report more spaciousness in both their body and psychology, and are therefore less triggered and reactive, and more proactive with the stressors of life 
  • The “volume” of the critical inner voice and big emotional waves is significantly turned down 
  • Reduced physical pain and tension
  • Reduction in symptoms of suicidal ideation
What is Ketamine-Assisted Psychedelic Therapy (KAPT)?

KAPT is a modality that combines our style of psychedelic therapy (Mindfulness-Based Psychedelic Therapy) with the medicinal and clinical effects of ketamine, Ketamine Assisted Psychotherapy, and oversight by licensed medical professionals. These sessions provide a full body and soul holistic psychedelic experience with the clinical and medical oversight required to work with this medicine safely and effectively. Sessions combine trauma-informed and evidence-based practices with mindfulness practices, ceremony, ritual, and somatic therapies, within a spiritual orientation and energetic/transpersonal paradigm (if requested). Ketamine serves as a catalyst to bring unconscious material into awareness within a non-ordinary state of consciousness while the therapist or guide is present to support clients with deepening and integrating these experiences.

At the Center for Medicinal Mindfulness, we support clients in working with ketamine, not only for symptom management or reduction, but also for addressing the root cause of why these symptoms manifested in the first place. In this setting, meaningful personal growth and transformation is common with this medicine, in addition to basic symptom management.

What to Expect from a Ketamine-Assisted Psychedelic Therapy Session

In your initial consultation and medical review, we will discuss treatment options and help you make an informed decision about whether this treatment is right for you.

Prior to KAPT treatment, clients are required to meet with our medical provider to explore the potential risks and benefits of this treatment. Following this, we provide preparation sessions to set goals and orient to the ketamine-assisted sessions. In our experience, the more a person prepares for the experience, the more they will get out of it.

KAPT sessions are typically three hours long and often include a booster dose. These sessions are tailored to each individual. Ketamine is prescribed either orally with lozenges, or administered by a medical professional intramuscularly via injection. Dosage is determined by our medical team and discussed with you prior to your session.

KAPT is often offered as a series of multiple sessions, so that each session can build on the next. This allows clients ample time and space to really get the most out of the process and truly experience the transformational benefits of this medicine.

Who is Ketamine for?

Ketamine-Assisted Psychedelic Therapy is an alternative treatment option for people seeking relief from depression, anxiety, trauma, addiction, or other major life challenges. This modality can work in conjunction with other forms of treatment, or can be used when other forms of treatment have not achieved one’s desired results or efficacy. It is also for people who are interested in-depth work, spiritual experience, and personal exploration.

We generally recommend starting with Ketamine if you are ready for the real work of psychedelic therapy, but need relief from acute symptoms to be resourced enough to do this work.

Is Ketamine a safe treatment?

Yes. Ketamine-Assisted Psychedelic Therapy is a safe treatment when administered and supervised by a team of trained professionals, and clients are appropriately screened and prepared for the experience. Before participating in KAPT with the Center for Medicinal Mindfulness, you will have a full medical evaluation performed by our medical providers. For decades, ketamine has been safely used with babies, the geriatric population and everyone in between.

What are Reasons Not To Take Ketamine?

There are several medical contraindications for using ketamine, and these will be discussed and reviewed in your medical review. In addition, while ketamine is helpful for depression in a bipolar episode, it is strongly contraindicated for anyone experiencing mania or psychosis.

What Makes a CMM Guided Experience with Ketamine Different?

Our standard ketamine session is scheduled for 3 hours, creating space for a deep journey and gentle landing. Many other ketamine clinics offer only 60-90 minute sessions with little to no therapeutic support. In typical medical ketamine clinics and private practice settings, clients are offered only low-dose (psycholytic) sessions instead of psychedelic ketamine sessions and are not provided with the psychological support needed to get the most benefit out of ketamine therapy. Our center is committed to maintaining best practices in KAPT and, because of that commitment to the healing and wellbeing of our clients, our approach offers much more than the medical-only trend.

Another factor that makes the Center for Medicinal Mindfulness different is that we also offer Cannabis-Assisted Psychedelic Therapy at our clinic. While some clients are intuitively drawn to just cannabis or just ketamine, many of our clients prefer a psychedelic therapy protocol which allows for multiple sessions with each medicine, known in our center as the Sanctuary Intensive (the medicines are not combined together in one session). Psychedelic cannabis and ketamine, while profoundly different from one another, work well together to address psychological and psychospiritual concerns from different angles. We also have ketamine and psilocybin mushroom intensives, which is also unique to our program. 

By combining a protocol in this way, clients are able to experience the best of all of our medicines safely (with medical oversight and professional guidance) and in a relatively short period of time.

What’s the difference between Intramuscular (IM), oral (aka lozenge or troche), and intravenous (IV) ketamine?

The Center for Medicinal Mindfulness offers two administration options for ketamine: Intramuscular (IM) injection and oral lozenges. Intravenous (IV) ketamine is also listed for additional information.

  • Intramuscular (IM) Ketamine – IM ketamine allows you to drop in and surrender completely. You are not tethered to an IV drip, you have the freedom to shift your body, to be fully covered in a blanket, to be fully immersed in the experience. Additionally, many people prefer IM ketamine due to the decrease in side effects, such as nausea, that are more prevalent with the lozenges, while still retaining the ability to fine tune your dosage. Overall, the experience feels less medical and more ceremonial. It can improve set, setting, and physical comfort, thus allowing you to fully explore and participate in the entire spectrum of the psychedelic experience.
  • Intravenous (IV) Ketamine – IV ketamine is administered at a lower dose over a 40-60 minute time period. While the IM experience will come on quickly and can be more intense as a psychedelic experience, the IV experience is a slow, steady experience that may feel lighter, depending on the flow rate. IV ketamine is more commonly used during the maintenance period, and may or may not include having a psychedelic guide in the room, depending on the experience of the client. This is a common practice in most IV ketamine clinics. While we always recommend professional support, some of our clients have substantial experience with this medicine and are more looking for a medical protocol for the recovery of chronic conditions. 
  • Sublingual (oral lozenge) Ketamine – Ketamine can also be administered by a lozenge or troche. This is a common and effective way in which KAPT occurs in many clinical settings. The lozenges are dissolved under the tongue, then held in the mouth for 15-20 minutes in order to fully achieve the medicine’s desired effect, and, for this reason, it can sometimes take a couple of sessions to find your preferred dose. Please note the lozenges have a bitter taste that some people find unpleasant, while others are not affected by the taste at all. In comparison to IM ketamine, which takes about 2-6 minutes for the onset of effects, sublingual experiences take a little longer to come on (usually about 15-30 minutes after administration), and sometimes the effects last longer than IM ketamine.

Sublingual ketamine may induce deeper psychedelic states, but it is not reliably as immersive as an IM experience. Lozenges are better than IV or IM for lower dose and psycholytic Ketamine-Assisted Psychotherapy (KAP) experiences as opposed to Ketamine-Assisted Psychedelic Therapy.

Lozenges require a medical evaluation and a prescription, but do not require a doctor on site to administer the medicine. This reduces the price, therefore making it more accessible to clients who can’t afford the intramuscular experience. Lozenges are available only to Colorado residents.

If intramuscular ketamine allows for a deeper experience, why is IV ketamine so common?

IV ketamine is the most common modality used by ketamine clinics for three reasons. The first is that many clinical trials involving ketamine use IV; this is not because IV ketamine is superior, rather that it allows a nurse to take blood samples before/after the ketamine is administered. The clinics often copy the study, not realizing it could be done differently. The second is that IV ketamine can be turned off in the middle of the procedure to gradually stop the experience if someone is having a difficult experience, since most ketamine clinics do not offer professional guiding support. Third, in solely medical models, the dose of ketamine provided over a longer period of time offers a less psychedelic experience and more of a sedating experience. This is beneficial to clients only seeking the physiological benefits of ketamine without having to navigate unknown unconscious material. 

The Center for Medicinal Mindfulness is a psychedelic therapy center that uses ketamine, not a typical medical ketamine clinic, and we believe the psychedelic nature of the experience is more often than not central to the healing process. Sometimes psychedelic experiences are difficult, and this isn’t for everyone, especially for those not trained in psychedelic therapy. All of the practitioners at Medicinal Mindfulness are competently able to educate our clients on how to engage big content and to safely guide our clients through a difficult experience. These difficult moments often turn out to be the most healing moments as well. Most other ketamine clinics do not have practitioners trained in holding space for big experiences, so they will stop the experience by turning off the IV instead. At CMM, we believe that this practice may impede true healing, and we don’t want to miss the opportunities that they present.

Part of any psychedelic experience is dropping in, trusting the process, and feeling prepared to face whatever shows up. IM ketamine asks you to fully engage with the process, which sets you up to fully engage in healing. For this reason, IM ketamine is our most common route of administration for our clients.

How is Ketamine legal?

As part of our client’s onboarding process, they are required to fill out several intake forms and have a medical review with one of our medical team members. This includes a safety assessment for ketamine, as well as either a prescription for working with ketamine lozenges, or as a preliminary assessment before a medical team member provides the IM shot at the beginning of the ketamine session. CMM works with a DEA licensed provider to provide ketamine to our clients. Lozenge prescriptions  are ordered for our clients, and the client can then pick up or have the order delivered to their residence (only for Colorado residents). CMM fully complies with all laws and regulations when it comes to the administration of ketamine.

Does CMM provide the medicine?

A licensed provider of ketamine provides intramuscular shots during the ketamine sessions, and the medicine is provided. Ketamine lozenges are prescribed and they can be picked up by the client at the pharmacy.